Joe (represented by Troika) played Chris in the original cast of Skins and currently plays Gendry in HBO's Game of Thrones. He was recently seen in BBC Two's drama Murder.
Skins, Kaya (represented by Curtis Brown) has starred in feature films including Wuthering Heights, and alongside Dakota Fanning in Now is Good. She will next be seen in US indie thriller Emanuel and the Truth about Fishes.
Nichola Burley, who starred alongside Kaya in Andrea Arnold's Wuthering Heights is also in the cast.
The four-parter, to be shown next year, explores the fallout from a series of shootings that take place in a single day in a fictional English market town. It explores tragedy, grief, responsibility and redemption seen through the eyes of a journalist returning to the small town of his childhood, and those closest to the victims of the tragedy.
Southcliffe also stars Rory Kinnear, Eddie Marsan (Vera Drake, Tyrannosaur) and Bafta-winning actress Shirley Henderson, along with Sean Harris (Prometheus), and Anatol Yusef (Boardwalk Empire).
Southcliffe is written by Tony Grisoni (Red Riding), produced by Derrin Schlesinger (Four Lions) for Warp Films, and will be the first UK television project for Sean Durkin, director of the 2011 independent US film Martha Marcy May Marlene.
"Southcliffe is a fictional market town inhabited by fictional characters, but with similarities to many actual people and places in Britain today," Grisoni said. "Invisible people, anonymous places. The inexplicable chain of events at the dark heart of this four-part drama shatters time and space for Southcliffe's inhabitants. Violence and sudden bereavement confronts them with emotions they are unequipped to understand. Rather than analyse or moralise about our characters' actions, we share in them. Southcliffe is an anthem to ordinary people's ability to reinvent themselves in the face of ultimate darkness."
Channel 4 head of drama Piers Wenger added: "Tony Grisoni's unique ability to convey the darkness and subtleties of human behaviour is in full evidence in these four brilliant scripts, and I'm delighted that Warp Films and Tony have found a world class director like Sean Durkin to bring them to life."
Southcliffe will start principle photography next month and be broadcast on Channel 4 in 2013.